Aim To ascertain the quantity and nature of gifts and items provided by the pharmaceutical industry in Australia to medical specialists and to consider whether these are appropriate in terms of justifiable ethical standards, empirical research and views expressed in the literature.

Routine management of geriatric problems often raises ethical problems, particularly regarding autonomy of the old person. The carers or children may be unaware of the sensitivity of role reversal in dealing with the financial affairs; the need for a residential carer may compromise the old person’s privacy. Attending a day centre confers much benefit, but one must understand the old person’s resistance to change in the proposal of a new daily regimen. Similarly his or her autonomy must be the priority (...) in planning for admittance to an old age home, and not the assumption that the family knows best. A common dilemma is the assessment of an old person’s competency in decision making, either about management of his affairs, or regarding consent to treatment, or participation in research. Because cognitive capacity is not always identical with competency, meaningful tools have recently been developed in which the emphasis is on the specific situation to be investigated. (shrink)

The practice around informed consent in clinical medicine is both inconsistent and inadequate. Indeed, in busy, contemporary health care settings, getting informed consent looks little like the formal process developed over the past sixty years and presented in medical textbooks, journal articles, and academic lectures. In this article, members of the Society of Teachers of Family Medicine (STFM) Collaborative on Ethics and Humanities review the conventional process of informed consent and its limitations, explore complementary and alternative approaches to doctor‐patient interactions, (...) and propose a new model of consent that integrates these approaches with each other and with clinical practice. The model assigns medical interventions to a consent continuum defined by the discrete categories of traditional informed consent, assent, and nondissent. Narrative descriptions and clinical exemplars are offered for each category. The authors invite colleagues from other disciplines and from the academic ethics community to provide feedback and commentary. (shrink)

Tr.: If I were to tell of suffering and bad billets, of scanty provisions ill set-out—but what was there we did not complain of when we did not get the day's ration? But, as for the dry ground, there was an even greater abomination in that; for our beds were close to the enemy's walls—for from heaven and earth they drenched us with the moisture of meadows, a constant affliction, making the wool of our cloaks foul.

The first international Newman Conference took place in Luxembourg from July 23rd till July 28th, 1956. Many representatives of various countries of Europe were present. Apart from the well nigh perfect organization, it was undoubtedly this common sympathy and admiration for Cardinal Newman that explains the extremely pleasant atmosphere that prevailed throughout these days. It was not, however, a dolce far niente, because every day was filled with addresses and lectures which in various ways and from differing points of view (...) tried to estimate the importance of Newman for the modern age. Some lecturers looked back into the history of the Cardinal and showed how in fact his works still held their message, couched in terms and modes of thinking that are in harmony with the deepest needs and desires of modern man. Others went farther and indicated lines along which a still more profound influence of Newman could be expected in the future. The whole of the conference consequently was something of a stocktaking showing the capital realized and the promises for the future. (shrink)

With the dawn of the day of the Battle of Salamis in ch. 83 of Book 8, Herodotus heightens the tone of his language. An unfortunate result of his more elaborately worked writing has been failure to understand his words, and hence much misplaced editorial intervention. In particular, the words at 8.83.1, προηγρενε εῢ Χοντα μν κ πντων Θεμιστοκλης, have regularly been mistranslated. Powell even wanted to rewrite the Greek here to read: γρευε μν πρó πντων Θεμιστοκλης . Few would (...) wish to follow such a drastic and arbitrary alteration of the transmitted text, but the conjectural emendation highlights the difficulty of understanding Herodotus' words at this point. (shrink)

There has been no major critical edition of Velleius with commentary since that of Kritz in 1840. Kritz, who took into account Sauppe's long essay on Velleius of three years earlier, was preceded by Ruhnken, whose commentary appeared in 1779. During the century which followed Kritz's work several valuable editions without commentary were produced, the last of which, by Stegmann de Pritzwald , almost coincided with the essay and bibliography devoted to Velleius in Schanz-Hosius . These two contributions of the (...) thirties remain standard to the present day. (shrink)

This is a marvelous book. Although billed as a Dogmatics, it is really a rambling and magnanimous presentation of the Christian faith-theology as well as practice. It is guided by the attempt to be systematic and comprehensive. It is filled with wonderful human insights into the nature of the Christian posture in a wayward world. It is part philosophical theology, part a theology of culture, and part practical theology. But it is more than all of its parts. What we have (...) is Hartt's mature ruminations on a vast number of subjects germane to Christian thinking. Hartt is a Barthian with humor, a neo-Reformation theologian with pizazz, a Methodist who has drunk deeply of American culture. Hartt divides his book into three parts: The Vocation of the Church as a Critic of Culture; The Dogmatic Content of Practical Theology; and Applications. The first part is an attempt to work the church into the role of a cultural interrogator, conscious on the one hand of its historic roots in that theological tradition known as the Christian faith, and on the other of its iconoclastic role, relativizing all absolutistic pretensions that civilization may attain, and in general, lose itself in the world, but not to the world. It is in this section that Hartt gives credence to the title of his book, A Christian Critique of American Culture. Part II emphasizes the "preachability" of the Gospel. Part III demonstrates what Hartt means by the applicability of the Gospel, its critique of art, politics, and mass culture. A chapter on "The Holy Spirit and 'Revolution'" concludes the work. There are no footnotes, no bibliography and no index. But none is needed. In the end what the reader has is Hartt and not a conglomeration and distillation of the thoughts of the theological luminaries of our day. Hartt's writing is the best among living theologians--and that fact alone ought to make anyone who is interested in great theologizing buy this book.--W. A. J. (shrink)

IF it is true that ‘all authentic philosophy is autobiographic‘. and that consequently one must understand the history of a man in order to understand his thought, it is obvious that no one, who has not shared the same national life, can fully enter into the living thoughts of a man like Newman, ‘an Englishman to the backbone’. That is why the remark was made in one of the debates at the Third International Newman Conference held in Luxembourg in 1964 (...) about the irreplaceable function of British scholarship in the study and evaluation of Newman. The process which Newman so admirably described of the development of an idea in the social sphere of either Church or State in his famous Essay is equally and perhaps more fundamentally true of the mind of the individual: we grow constantly towards maturer views—true or false—because of innumerable influences, impressions, tendencies ‘in the air’, ‘floating opinions’, principles surrounding us and the more powerful minds, if they express themselves strikingly, will influence the social scene, perhaps unconsciously or even unwillingly, from the mighty platform of public media of communication or via small circles of devoted friends, in a thousand ways which we have hardly begun to trace and of which many will remain totally hidden. The flux is so constant and so multifarious that we wonder how we can speak of historicity, but there it is: one fine day the entire world arose and found itself Arian. Newman lived very actively and intensely and for a long time in one of the very centres of the intellectual life of a great nation. ‘Universities are the natural centres of intellectual movements‘. Thus the remark made on the continent was the expression of the honest realisation of an essential handicap in foreign scholars. They asked for help in a matter they could not possibly supply themselves, and we are happy to be able to say that this help is generously supplied. It is precisely one of the aims of this article to consider some of the results. Though all this is undoubtedly true we are still facing the fact that: ‘in England Newman never seems quite to make it’. What forces bring this about? (shrink)

Community engagement is increasingly promoted as a marker of good, ethical practice in the context of international collaborative research in low-income countries. There is, however, no widely agreed definition of community engagement or of approaches adopted. Justifications given for its use also vary. Community engagement is, for example, variously seen to be of value in: the development of more effective and appropriate consent processes; improved understanding of the aims and forms of research; higher recruitment rates; the identification of important ethical (...) issues; the building of better relationships between the community and researchers; the obtaining of community permission to approach potential research participants; and, the provision of better health care. Despite these diverse and potentially competing claims made for the importance of community engagement, there is very little published evidence on effective models of engagement or their evaluation. (shrink)

Seventeenth-century philosophy scholars come together in this volume to address the Insiders--Descartes, Spinoza, Leibniz, Locke, and Hobbes--and Outsiders--Pierre Gassendi, Kenelm Digby, Theophilus Gale, Ralph Cudworth and Nicholas Malebranche--of the philosocial canon, and the ways in which reputations are created and confirmed. In their own day, these ten figures were all considered to be thinkers of substantial repute, and it took some time for the Insiders to come to be regarded as major and original philosophers. Today these Insiders all feature in (...) the syllabi of most history of philosophy courses taught in western universities, and the papers in this collection, contrasting the stories of their receptions with those of the Outsiders, give an insight into the history of philosophy which is generally overlooked. (shrink)

David A. J. Richards's Resisting Injustice and The Feminist Ethics of Care in The Age of Obama: Suddenly,...All The Truth Was Coming Out examines the roots of the resistance movements of the 1960s, the political psychology behind contemporary conservatism, and President Obama's present-day appeal as well as the reasons for the reactionary politics against him. This book positions recent American political development in a broad analysis of the role of patriarchy in human oppression throughout history, and argues that a feminist-based (...) ethics of care is necessary to form a more humane and inclusive democratic politics. (shrink)

1. Introduction . In the chapter which he devotes to the applications of his principle of individual liberty, Mill considers the question ‘how far liberty may legitimately be invaded for the prevention of crime, or of accident’. On the latter topic, he writes:—‘… it is a proper office of public authority to guard against accidents. If either a public officer or anyone else saw a person attempting to cross a bridge which had been ascertained to be unsafe, and there were (...) no time to warn him of his danger, they might seize him and turn him back, without any real infringement of his liberty; for liberty consists in doing what one desires, and he does not desire to fall into the river.”. (shrink)

This is the first comprehensive study of the sublime in Lucan. Drawing upon renewed literary-critical interest in the tradition of philosophical aesthetics, Henry Day argues that the category of the sublime offers a means of moving beyond readings of Lucan's Bellum Civile in terms of the poem's political commitment or, alternatively, nihilism. Demonstrating in dialogue with theorists from Burke and Kant to Freud, Lyotard and Ankersmit the continuing vitality of Longinus' foundational treatise On the Sublime, Day charts Lucan's complex and (...) instructive exploration of the relationship between sublimity and ethical discourses of freedom and oppression. Through the Bellum Civile's cataclysmic vision of civil war and metapoetic accounts of its own genesis, through its heated linguistic texture and proclaimed effects upon future readers and, most powerfully of all, through its representation of its twin protagonists Caesar and Pompey, Lucan's great epic emerges as a central text in the history of the sublime. (shrink)

In disproof of the materialist principle, that common things exist unperceived, and in defence of the New Principle, Philonous here objects that it is inconceivable that a common thing should do so. Hylas replies that, on the contrary, we can and do think of, e.g., a tree standing alone as opposed to a tree being perceived by an observer. But Philonous counter-objects to this reply that it contains a contradiction, since it asserts that we can think of something which is (...) not thought of. (shrink)

Both these developments would have surprised Berkeley. He would have found it paradoxical that the vulgar should have rejected his vulgar immaterialism as paradoxical, since he of course believed himself to be on their side in the matter, and characterised his own philosophy as a.

Peter Geach supports his case that the religion of Thomas Hobbes was both genuine and a version of Socinianism principally by comparing the theological and scriptural sections of Leviathan with the main doctrines of Socinianism and its latter-day developments in Unitarianism and Christadelphianism. He pays particular attention to comparisons with the Racovian Catechism, the theological writings of Joseph Priestley and the Christadelphian document Christendom Astray by Robert Roberts.

According to Berkeley, then, the unconscious process of inference of the scientist goes as follows. He notices that, when he does not have his house within visual range, he cannot see it just by wishing to; and that, when he does have it within visual range and his eyes open, he cannot prevent himself from seeing it just by wishing not to. He therefore infers that he is not the efficient cause of these sensations. But, since he holds that they (...) must have some efficient cause, he concludes that this is a congeries of "material substances," which are numerically distinct and partly dissimilar from the sensations, and which exist even when unperceived, or "externally to the mind." As a psychological theory, this seems to be at any rate plausible. (shrink)

Human conflict and its resolution is obviously a subject of great practical importance. Equally obviously, it is a vast subject, ranging from total war at one end of the spectrum to negotiated settlement at its other end. The literature on the subject is correspondingly vast and, in recent times, technical, thanks to the valuable contributions made to it by game theorists, economists, and writers on industrial and international relations. In this essay, however, I shall discuss only one familiar form of (...) conflict-resolution. There is room for such a discussion, because philosophers have lately neglected compromise, despite the interest shown in it by the aforementioned experts, and despite the classic treatments of it by Halifax, Burke and Morley. Truly, ‘…compromise is not so widely discussed by philosophers as one might expect’, and ‘…the idea of compromise has been largely neglected by Anglo-American jurisprudence’. (shrink)

In this Open Peer Commentary, we draw on our clinical experience to argue that instrumental paternalism carves a pathway to competent refusal of medical intervention. Whether C successfully navigat...

Mill holds a metaphysical theory about the nature of things which is of the sensationalist or phenomenalist variety, and which he derives admittedly from the idealism of Berkeley. This metaphysical theory is introduced into a discussion in which he is attempting something different, namely, to offer a rival psychological account to Hamilton's intuitionist one of how it is that men possess that familiar but complex conception, Nature or the external world. It will be convenient to consider his psychological theory first.

Like theories of punishment, theories of reverse discrimination can usefully be divided into forward-looking ones and backward-looking ones. One example of the former type of theory is Dworkin's, who defends the policy on the ground that it will produce ‘a more equal society’. Another is Sher's, who defends it on the ground that it increases equality of opportunity. This essay is an examination of the latter type of theory. Compensatory discrimination is related, then, to discrimination thus: discrimination is the genus, (...) of which reverse discrimination is a species, of which compensatory discrimination is a sub-species. It will be convenient to proceed by examining successively the ideas of discrimination, of compensation, and of compensatory discrimination. (shrink)

This discussion completes 'Moral Dilemmas, Compromise and Compensation' ("Philosophy", Vol. 66. No. 257, July 1991). In correction of the earlier discussion, the claim that resolution of moral dilemmas by compromise is always preferable to resolution by compensation, is withdrawn. In a particular case, the decision which is preferable requires judgment (Subsec. 3.8). In amplification of the earlier discussion, it is observed that another way of resolving moral conflicts is what M P. Follett calls 'Integration'. In this, the one claimant is (...) made better off and the other claimant is made no worse off. This is in fact an application of a principle of Pareto's. Here again, in a particular case, the decision whether resolution by integration is preferable to resolution by compromise, requires judgment (Subsec. 3.5). (shrink)

Since January 2016, the Mahidol Oxford Tropical Medicine Research Unit has trialled a data-sharing policy where requests to access research datasets are processed through a Data Access Committee. In this paper, we share our experiences establishing data management systems and data-sharing infrastructure including a data-sharing policy, data access committee and related procedures. We identified a number of practical and ethical challenges including requests for datasets collected without specific or broad consent to data sharing and requests from pharmaceutical companies for data (...) to support drug registration applications. We also encountered significant resource constraints which required the development of appropriate human resources and infrastructure. We suggest a research agenda to promote responsible and equitable data sharing while safeguarding the rights and interests of research participants and researchers. (shrink)

Apart from the names of Jan Baudouin de Courtenay (1845-1929), Mikołaj Kruszewski (1851-1887), and, later, Jerzy Kuryłowicz (1895-1978), Polish linguists and Polish linguistics generally have been little known in the West. The first two were mentioned with approval by Saussure in an unpublished paper, and this reference was picked up by Roman Jakobson and others many years later. Kuryłowicz, for his part, made himself well known in the West through his important work as Indo-Europeanist, even Semiticist, and as a general (...) linguist. The present volume is a first attempt to broaden the perspectives on the Polish contribution to linguistics both inside and outside of Poland during the past centuries. Specialists in their respective fields contributed chapters on the origins and development of general linguistics (Z. Wąsik), applied linguistics (F. Grucza), lexicology (T. Piotrowski), dialectology (St. Gogolewski), and onomastics (S. Gala), followed by five chapters presenting the theories of the arguably most remarkable Polish linguistic thinkers, from Baudouin de Courtenay (A. Adamska-Sałaciak), Kruszewski (F. M. Berezin), and Kuryłowicz (W. Smoczyński) to Mikołaj Rudnicki (1881-1978) and Ludwik Zabrocki (1907-1977) (both written by J. Bańczerowski). Detailed individual bibliographies, a full index of names (with life dates of Polish linguists from the Renaissance to the present day), and a thorough index of subjects and terms make this volume an important reference tool for anyone wishing to acquaint himself with the rich heritage of Polish linguistic thought. (shrink)

We question the usefulness of Pylyshyn's dichotomy between cognitively penetrable and cognitively impenetrable mechanisms as the basis for his distinction between cognition and early vision. This dichotomy is comparable to others that have been proposed in psychology prompting disputes that by their very nature could not be resolved. This fate is inevitable for Pylyshyn's thesis because of its reliance on internal representations and their interpretation. What is more fruitful in relation to this issue is not a difficult dichotomy, but a (...) different look at perception such as proposed by Gibson (1979). (shrink)

Hitherto, the standard edition of Berkeley's works has been A. C. Fraser's of 1901, published by the Oxford University Press. The chief differences between the two editions are these. Professors Luce and Jessop give of each text the latest edition published by Berkeley himself, adding all significant variations in any earlier editions in footnotes, whereas Fraser followed no uniform procedure, and sometimes combined different editions. This difference is obviously an improvement. Further, Professor Luce's edition of Berkeley's pair of notebooks, which (...) he calls Philosophical Commentaries and which Fraser called Commonplace Book of occasional metaphysical thoughts, differs radically from Fraser's; Professor Luce has also given a different, and better, text of the Theory of Vision Vindicated. Finally, Volume II of the new edition amplifies Berkeley's brief correspondence with the American philosopher, Samuel Johnson, since it contains Johnson's letters to Berkeley, in which he questions some points in Berkeley's system, whereas Fraser published Berkeley's replies only. The editors' notes and introductions are brief, and have been written with the primary aim of presenting an accurate text. This policy is welcome, since it remains all too true that, as Professor Jessop remarks, "hitherto Berkeley has been read far too little, and his expositors far too much"; which, in the case of so excellent a writer as Berkeley, is doubly a pity. (shrink)

This is the introduction to Seeing Wittgenstein Anew, eds. William Day & Victor J. Krebs (Cambridge UP, 2010), a collection of essays on Ludwig Wittgenstein's remarks on aspect-seeing. Section 1: Why Seeing Aspects Now?; Section 2: The Importance of Seeing Aspects; Section 3: The Essays. (The front matter to Seeing Wittgenstein Anew appears above under "Books.").

Seeing Wittgenstein Anew is the first collection to examine Ludwig Wittgenstein’s remarks on the concept of aspect-seeing. These essays show that aspect-seeing was not simply one more topic of investigation in Wittgenstein’s later writings, but, rather, that it was a pervasive and guiding concept in his efforts to turn philosophy’s attention to the actual conditions of our common life in language. Arranged in sections that highlight the pertinence of the aspect-seeing remarks to aesthetic and moral perception, self-knowledge, mind and consciousness, (...) linguistic agreement, philosophical therapy, and “seeing connections,” the sixteen essays, which were specially commissioned for this volume, demonstrate the unity of not only Philosophical Investigations but also Wittgenstein’s later thought as a whole. They open up novel paths across familiar fields of thought: the objectivity of interpretation, the fixity of the past, the acquisition of language, and the nature of human consciousness. Significantly, they exemplify how continuing consideration of the interrelated phenomena and concepts surrounding aspect-seeing might produce a fruitful way of doing philosophy. The volume includes a concordance for the unnumbered remarks in the various editions of Philosophical Investigations, including the latest (4th) edition. (The front matter is posted here. The introduction - "Seeing Aspects in Wittgenstein" - appears below under "Published articles."). (shrink)

Moral dilemmas, or moral conflicts, present a leading problem in Ethics. Ross calls them the problem of conflicting prima facie moral obligations. Lemmon calls them ‘moral dilemmas’, and Sinnott-Armstrong in his recent book discusses them thoroughly and provides extensive references to relevant literature.

BackgroundCommunity engagement is increasingly promoted as a marker of good, ethical practice in the context of international collaborative research in low-income countries. There is, however, no widely agreed definition of community engagement or of approaches adopted. Justifications given for its use also vary. Community engagement is, for example, variously seen to be of value in: the development of more effective and appropriate consent processes; improved understanding of the aims and forms of research; higher recruitment rates; the identification of important ethical (...) issues; the building of better relationships between the community and researchers; the obtaining of community permission to approach potential research participants; and, the provision of better health care. Despite these diverse and potentially competing claims made for the importance of community engagement, there is very little published evidence on effective models of engagement or their evaluation.MethodsIn this paper, drawing upon interviews with the members of a Community Advisory Board on the Thai-Myanmar border, we describe and critically reflect upon an approach to community engagement which was developed in the context of international collaborative research in the border region.Results and conclusionsDrawing on our analysis, we identify a number of considerations relevant to the development of an approach to evaluating community engagement in this complex research setting. The paper also identifies a range of important ways in which the Community Advisory Board is in practice understood by its members to have morally significant roles and responsibilities beyond those usually associated with the successful and appropriate conduct of research. (shrink)

This study examined whether worktime control buffered the impact of worktime demands on work-family interference (WFI), using data from 2,377 workers from various sectors of industry in The Netherlands. We distinguished among three types of worktime demands: time spent on work according to one's contract (contractual hours), the number of hours spent on overtime work (overtime hours), and the number of hours spent on commuting (commuting hours). Regarding worktime control, a distinction was made between having control over days off and (...) vacations (leave control) and having control over starting and finishing times (flextime). These three worktime demands were expected to have separate as well as joint effects on WFI, whereas worktime control should buffer these adverse effects of worktime demands on WFI. Stepwise regression analyses showed that working high numbers of contractual and overtime hours was indeed associated with high WFI. Further, worktime control indeed made a difference in terms of WFI: whereas leave control contributed directly to lower WFI, flextime buffered the adverse effects of long contractual workhours. Our results suggest that very long working days should be prevented, and that worktime control may be a powerful tool to help workers maintaining a good work-family balance. (shrink)

Over the past decades, mood enhancement effects of various drugs and neuromodulation technologies have been proclaimed. If one day highly effective methods for significantly altering and elevating one’s mood are available, it is conceivable that the demand for them will be considerable. One urgent concern will then be what role physicians should play in providing such services. The concern can be extended from literature on controversial demands for aesthetic surgery. According to Margaret Little, physicians should be aware that certain aesthetic (...) enhancement requests reflect immoral social norms and ideals. By granting such requests, she argues, doctors render themselves complicit to a collective ‘evil’. In this paper, we wish to question the extent to which physicians, psychiatrists and/or neurosurgeons should play a role as ‘moral gatekeepers’ in dealing with suspect demands and norms underlying potential desires to alter one’s mood or character. We investigate and discuss the nature and limits of physician responsibilities in reference to various hypothetical and intuitively problematic mood enhancement requests. (shrink)

This book is a qualitative, interpretive, phenomenological, and interdisciplinary, examination of food and food practices and their meanings in the modern world. Each chapter thematically focuses upon a particular food practice and on some key details of the examined practice, or on the practice’s social and cultural impact.

Johanna Knapstein,1 Daniel Grimm,1 Marcus A Wörns,1 Peter R Galle,1 Hauke Lang,2 Tim Zimmermann111st Department of Internal Medicine, Johannes Gutenberg-University, Mainz, Germany; 2Department of General, Visceral and Transplantation Surgery, Johannes Gutenberg-University, Mainz, GermanyIntroduction: Hepatitis C virus reinfection occurs universally after liver transplantation, with accelerated cirrhosis rates of up to 30% within 5 years after liver transplantation. Dual antiviral therapy with pegylated interferon-2a and ribavirin only reaches sustained virological response rates of ~30% after liver transplantation. With the approval of viral NS3/4A (...) protease inhibitors telaprevir, boceprevir, and simeprevir and the NS5B polymerase inhibitor sofosbuvir, combination therapy offers new therapeutic options for HCV-infected patients, resulting in considerably higher sustained virological response rates in the nontransplant setting. Case presentation: We report three cases of TVR-based triple antiviral therapy in HCV genotype 1 reinfected patients after liver transplantation, of whom a 57-year-old Caucasian female and a 43-year-old Caucasian male were therapy naïve, and a 49-year-old Caucasian male patient was pretreated ineffectively. After 4 weeks of therapy, viral load decreased one to three log10 and became negative in weeks 6 to 8 in the therapy naïve patients. The pretreated patient showed a negative viral load in week 4. TVR was administered over 12 weeks, 750 mg thrice daily. Doses of immunosuppression with cyclosporine were reduced four to six fold. Initial peg-IFN and RBV doses ranged from 135–180 µg/week and 800–1,200 mg/day, according to the patient's body weight. Doses of peg-IFN and RBV were adapted to 90–135 µg/week and 400–800 mg/day after 2 to 12 weeks of protease inhibitor therapy. Dual therapy was continued for 36 weeks with total treatment duration of 48 weeks in the therapy naïve patients leading to a sustained virological response 12 weeks after the end of therapy. In the pretreated patient a breakthrough was detected in week 24 and therapy was discontinued. Overall, antiviral therapy was well tolerated. Side effects included dysgeusia and anemia leading to erythropoietin application and blood transfusions. Conclusion: This case series emphasizes that triple therapy with TVR is an efficient treatment for therapy naïve HCV genotype 1 reinfected patients after liver transplantation. But therapeutic options for pretreated patients require improvement. Keyword: cyclosporine, interferon, ribavirin, hepatitis C, protease inhibitor. (shrink)